Pascal Tshiamala KK1,
Ganiyat Oyeleke2,
Bright Nsokolo3,
Felix Aninagyei4,
Rajesh Sirwani5 
,
Sunil Nair6
For correspondence:- Rajesh Sirwani Email: rajesh.sirwani@shalina.com Tel:+9714430 9111
Accepted: 28 October 2022 Published: 30 November 2022
Citation: Tshiamala KK P, Oyeleke G, Nsokolo B, Aninagyei F, Sirwani R, Nair S. Comparative evaluation of Polygel Dual and commonly used alginate-antacid formulations (ACIDUAL Study). Trop J Pharm Res 2022; 21(11):2279-2284 doi: 10.4314/tjpr.v21i11.2
© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To compare Polygel Dual (PD) and four marketed alginate-antacid combination products, with respect to raft formation and antacid properties.
Methods: The pharmacopeial tests used were selected based on demonstrable performance of raft-forming potential, including speed and thickness, for all selected products. Evidence-based methods were used to determine the antacid effects in terms of acid-neutralizing capacity and increase in pH.
Results: Raft-forming ability was demonstrated by three products, with AF-4 and PD outperforming in speed and thickness. PD, AF-1 and AF-2 exhibited superior antacid properties. However, PD was the only product that demonstrated superior performance with respect to raft-formation and antacid potential. Raft-forming capacity was exhibited by 3 out of 5 products, viz, PD, AF-1 and AF-4. Raft formation was faster in AF-4 (15 s), followed by in PD (25 s). Similarly, raft thickness (14.79 mm) was highest in AF-4, followed by (4.39 mm) in PD. Preliminary antacid test results showed that AF-4 failed to raise pH above 3.5, but PD raised pH to 5.86, while AF-1 raised pH to 5.88. Similarly, periodic test analysis revealed that PD maintained pH above 7 for the entire test duration of 210 min, whereas AF-4 failed to raise pH to 7 during the test period.
Conclusion: Polygel dual (PD) demonstrates desirable raft-forming potential and antacid properties. Moreover, it effectively raises pH and maintains it for longer duration than any of the other antacid products. Thus, PD may be considered a potentially effective treatment for acid-reflux problems. However, this claim should be validated in suitable clinical trials.
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